https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 CD151, a laminin receptor showing increased expression in asthmatic patients, contributes to airway hyperresponsiveness through calcium signaling https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32970 in vitro, ex vivo, and in vivo. Results The number of CD151⁺ ASM cells is significantly greater in patients with moderate asthma compared with those in healthy nonasthmatic subjects. From loss- and gain-of-function studies, we reveal that CD151 is required for and enhances G protein-coupled receptor (GPCR)-induced peak intracellular calcium release, the primary determinant of excitation-contraction coupling. We show that the localization of CD151 can also be perinuclear/cytoplasmic and offer an explanation for a novel functional role for CD151 in supporting protein kinase C (PKC) translocation to the cell membrane in GPCR-mediated ASM contraction at this site. Importantly, CD151-/- mice are refractory to airway hyperreactivity in response to allergen challenge. Conclusions We identify a role for CD151 in human ASM contraction. We implicate CD151 as a determinant of AHR in vivo, likely through regulation of GPCR-induced calcium and PKC signaling. These observations have significant implications in understanding the mechanism for AHR and the efficacy of new and emerging therapeutics.]]> Wed 17 Nov 2021 16:31:54 AEDT ]]> Oolemmal proteomics : identification of oocyte cell surface protein complexes involved in murine fertilisation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2940 Wed 11 Apr 2018 16:05:16 AEST ]]> Tetraspanins as biomarkers and causative proteins in prostate cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13633 Wed 11 Apr 2018 12:19:23 AEST ]]> Post-transcriptional regulation of tetraspanins CD151 and CD9 by micro-RNAs in prostate and breast cancers https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21979 Wed 11 Apr 2018 11:16:20 AEST ]]> Deletion of Cd151 reduces mammary tumorigenesis in the MMTV/PyMT mouse model https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16760 −/− PyMT mice compared to Cd151+/+ PyMT littermate controls, this result was only approaching significance (Log-rank test P-value =0.0536). Interestingly, Cd151 deletion resulted in significantly reduced numbers and size of primary tumors but did not appear to affect the number or size of metastases in the MMTV/PyMT mice. Intriguingly, no differences in the expression of markers of cell proliferation, apoptosis and blood vessel density was observed in the primary tumors. Conclusion: The findings from this study provide additional evidence that CD151 acts to enhance tumor formation initiated by a range of oncogenes and strongly support its relevance as a potential therapeutic target to delay breast cancer progression.]]> Wed 11 Apr 2018 10:43:04 AEST ]]> The tetraspanin CD151’s role in the kidney and mapping of genetic modifiers of glomerular disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21095 Wed 11 Apr 2018 09:42:34 AEST ]]> A platelet tetraspanin superfamily member, CD151, is required for regulation of thrombus growth and stability in vivo https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7013 Sat 24 Mar 2018 08:38:04 AEDT ]]> Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7003 Sat 24 Mar 2018 08:37:49 AEDT ]]> Characterization of mice lacking the tetraspanin superfamily member CD151 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1881 Sat 24 Mar 2018 08:31:18 AEDT ]]> Knockout of the tetraspanin Cd9 in the TRAMP model of de novo prostate cancer increases spontaneous metastases in an organ-specific manner https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20184 Sat 24 Mar 2018 07:51:43 AEDT ]]> The role of the tetraspanin CD151 in primary keratinocyte and fibroblast functions: implications for wound healing https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5569 Sat 24 Mar 2018 07:49:28 AEDT ]]>